Joseph B. Shrager

This study develops iPSC-derived T cells targeting the EGFR C797S mutation in NSCLC, showing their ability to recognize and kill cancer cells expressing this mutation.

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

The paper introduces REMI, a graph-based method to reconstruct cell-cell interactions in lung adenocarcinoma by accounting for ligand-receptor dependencies, and validates its findings experimentally.

The paper creates a comprehensive molecular cell atlas of the human lung using single-cell RNA sequencing, identifying 58 cell populations including 14 new types and revealing evolutionary changes in lung cell types.

The paper maps EMT and MET states in lung cancer using single-cell resolution and a novel computational tool, showing differences in trajectories and providing a framework for clinical sample characterization.