Michal Kucharski

This study identifies host adaptation barriers in Plasmodium knowlesi by analyzing multi-omic data from parasites cultured in human and macaque red blood cells.

This study uses transcriptomics to show dihydroartemisinin induces a two-step transcriptional response in malaria parasites, with trophozoites showing the strongest response and a reversal of developmental stages.

This study identifies parasite-intrinsic transcriptional programs associated with severe P. knowlesi malaria through integrative GWAS, transcriptomic, and eQTL analyses of clinical isolates.

The paper analyzes P. knowlesi genomes from Sabah, Malaysia, to identify genetic subpopulations and introgression events linked to environmental factors and host adaptation.

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.