Matthew J. Grigg

The paper identifies pfcrt copy number amplification as a new antimalarial resistance mechanism in Plasmodium falciparum and develops a TaqMan assay for its detection.

This study identifies parasite-intrinsic transcriptional programs associated with severe P. knowlesi malaria through integrative GWAS, transcriptomic, and eQTL analyses of clinical isolates.

The paper identifies a conserved complex formed by PTRAMP, CSS, and Ripr in Plasmodium species that facilitates merozoite invasion of erythrocytes and shows its structural and functional conservation across species.

The paper maps the geographic distribution and host associations of MaRNAV-1, a virus linked to Plasmodium vivax, using metatranscriptomic data.

The paper investigates age-related differences in inflammatory responses to malaria, finding that adults exhibit heightened inflammatory cytokine production and distinct transcriptional responses compared to children.

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.

The paper analyzes P. knowlesi genomes from Sabah, Malaysia, to identify genetic subpopulations and introgression events linked to environmental factors and host adaptation.

The paper identifies a novel RNA virus in zoonotic Plasmodium knowlesi isolates, showing it belongs to an unclassified viral taxon called ormycoviruses.

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.