Ernest Diez Benavente

Integrative genomics of Plasmodium knowlesi reveals parasite-intrinsic regulators of severe human malaria

This study identifies parasite-intrinsic transcriptional programs associated with severe P. knowlesi malaria through integrative GWAS, transcriptomic, and eQTL analyses of clinical isolates.

Sex-Specific Regulation of Endothelial-to-Mesenchymal Transition (EndMT) During Atherosclerosis

The paper examines sex-specific regulation of EndMT in atherosclerosis using bulk RNA-seq and single-cell transcriptomics, identifying key regulators and stage-dependent differences.

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease

The paper integrates multi-modal omics data to identify therapeutic pathways in atherosclerosis for coronary heart disease, highlighting amino acid metabolism and 16 relevant proteins.

Identification of endothelial-to-mesenchymal transition gene signatures in single-cell transcriptomics of human atherosclerotic tissue

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

The paper identifies female-biased VSMC gene regulatory networks and highlights MYH9 as a key regulator of fibrous plaque phenotype in females.

Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.

The paper analyzes P. knowlesi genomes from Sabah, Malaysia, to identify genetic subpopulations and introgression events linked to environmental factors and host adaptation.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

Getting close to nature - Plasmodium knowlesi reference genome sequences from contemporary clinical isolates

The paper develops a method to generate comprehensive genome sequences of Plasmodium knowlesi from clinical isolates and provides insights into the evolution of gene families associated with antigenic variation.

Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes

The paper identifies eQTLs and sQTLs in human aortic SMCs that colocalize with CAD GWAS loci, highlighting splicing regulation as a mechanism for CAD risk.