Zbynek Bozdech

Multi-omic profiling of Plasmodium knowlesi blood stages identifies host adaptation barriers

This study identifies host adaptation barriers in Plasmodium knowlesi by analyzing multi-omic data from parasites cultured in human and macaque red blood cells.

Thermal proteome profiling identifies new drug targets in Plasmodium falciparum parasites

The paper identifies new drug targets in Plasmodium falciparum using thermal proteome profiling combined with molecular docking and MS-CETSA.

A chromosome-scale Plasmodium cynomolgi Berok genome reveals a distinct subtelomeric architecture and a highly diverged primate malaria lineage

Dihydroartemisinin induces a two-step transcriptional response and stage-specific developmental shifts in malaria parasites, Plasmodium falciparum

This study uses transcriptomics to show dihydroartemisinin induces a two-step transcriptional response in malaria parasites, with trophozoites showing the strongest response and a reversal of developmental stages.

Integrative genomics of Plasmodium knowlesi reveals parasite-intrinsic regulators of severe human malaria

This study identifies parasite-intrinsic transcriptional programs associated with severe P. knowlesi malaria through integrative GWAS, transcriptomic, and eQTL analyses of clinical isolates.

Inhibition of PfCLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malaria

This study shows that inhibiting PfCLK3 disrupts RNA-splicing in malaria parasites, affecting 1125 genes and providing a novel mechanism for a radical cure.

Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.

The paper analyzes P. knowlesi genomes from Sabah, Malaysia, to identify genetic subpopulations and introgression events linked to environmental factors and host adaptation.

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

Genetic validation of PfFKBP35 as an antimalarial drug target

This study genetically validates PfFKBP35 as a lethal target in Plasmodium falciparum, showing its role in ribosome homeostasis and revealing non-canonical modes of action for FK506.

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

Antagonistic roles of NOT1 paralogues in the timing of gene expression in Plasmodium falciparum

This study shows that two NOT1 paralogues in Plasmodium falciparum have opposing roles in regulating mRNA abundance during the intraerythrocytic developmental cycle.