Author

Floris J. van Eerden

Immunology Frontier Research Center, The University of OsakaORCID 0000-0002-1510-0544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Approach:simulation· 1

Frequent Co-Authors

Daron M. StandleyiD· 2 shared A. SherifiD· 1 shared Arthur MilliusiD· 1 shared Christoph GerleiD· 1 shared David Virya CheniD· 1 shared Fuminori SugiharaiD· 1 shared Hendra Saputra IsmantoiD· 1 shared Hisashi AraseiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Daron M. StandleyORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 21, 2024

Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes

Floris J. van Eerden, Songling Li, Tina Lusiany…·Daron M. Standley

This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.

DOI 10.1101/2024.08.21.608921

protein structurestatistical model

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 27, 2022

TCR-pMHC complex formation triggers CD3 dynamics

Floris J. van Eerden, A. Sherif, Mara Anaís Llamas-Covarrubias…·Daron M. Standley

This study identifies an allosteric mechanism where TCR-pMHC binding induces CD3 dynamics through conformational changes, with the TCRβ FG loop acting as a gatekeeper and the connecting peptide as a hinge.

6 citations

protein structurestatistical model

𝕏 PostBluesky