Christoph Gerle

Polymorphic Structures of an Artificial Nucleocapsid Evolved from a Circularly Permuted Bacterial Protein Cage

This study evolves an artificial nucleocapsid from a circularly permuted bacterial protein cage, revealing heterogeneous cage architectures with distinct subunit arrangements and conformations.

A planar dimer of bovine ATP synthase

The paper identifies a planar dimeric form of bovine ATP synthase with minimal membrane bending, contrasting with canonical dimers that induce significant curvature.

Monomer-dimer structural comparison in quinol-dependent nitric oxide reductase reveals a functional basis for superior enzymatic activity in the dimer

The paper compares monomer and dimer structures of NmqNOR to show how dimerization enhances enzymatic activity by stabilizing the active site conformation.

High-resolution Cryo-EM visualises hydrated type I and IV pilus structures from enterotoxigenic Escherichia coli

This study uses cryo-EM to determine high-resolution structures of type I and IV pili from enterotoxigenic Escherichia coli, revealing subunit interactions and hydrated water molecules.

Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes

This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.

Structure and function of the intermembrane space domain of mammalian FoF1 ATP synthase

This study determines the structure and function of the intermembrane space domain in mammalian FoF1 ATP synthase using cryo-EM and biochemical analysis.