Hisashi Arase

Dual blockade of LILRB1 and LILRB2 enhances antiviral immune responses in SIV infection

This study shows that blocking LILRB1 and LILRB2 with a dual-specific antibody enhances antiviral immune responses in SIV infection without adverse effects.

Immune-induced TCR-like antibodies regulate specific T cell response

This study identifies immune-induced TCR-like antibodies (iTabs) that inhibit T cell receptor recognition of antigen-presenting MHC class II molecules, offering a strategy to suppress autoimmune disease.

RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1

The paper identifies RIFINs that bind both inhibitory and activating KIR receptors, revealing their role in modulating NK cell activation during malaria infection.

Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes

This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.