Author

A. A. Sherif

Research Institute for Microbial Diseases, The University of OsakaORCID 0000-0002-5692-6887Unclaimed ORCID profile · follow to get notified of new preprints

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A. A. Sherif2 papers

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Daron M. StandleyiD· 2 shared Abdullah KhasawnehiD· 1 shared Arthur MilliusiD· 1 shared Chikako OnoiD· 1 shared Dianita S. SaputriiD· 1 shared Faith Jessica ParaniD· 1 shared Floris J. van EerdeniD· 1 shared Hendra Saputra IsmantoiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Daron M. StandleyORCID

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2 papers

Recent·Most cited

BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis

Faith Jessica Paran, Rieko Oyama, Abdullah Khasawneh, Tomohiko Ai, Hendra Saputra Ismanto, A. A. Sherif, Dianita S. Saputri, Chikako Ono, Mizue Saita, Satomi Takei, Yuki Horiuchi, Ken Yagi, Yoshiharu Matsuura, Yasushi Okazaki, Kazuhisa Takahashi, , Toshio Naito

This study finds that BCR repertoire diversity, not TCR diversity, correlates with favorable outcomes in COVID-19 patients.

Frontiers in Immunology · Oct 28, 2024Peer-reviewedImmunology

TCR-pMHC complex formation triggers CD3 dynamics

Floris J. van Eerden, A. Sherif, Mara Anaís Llamas-Covarrubias, Arthur Millius, Xiuyuan Lu, Shigenari Ishizuka, Sho Yamasaki, Daron M. Standley

This study identifies an allosteric mechanism where TCR-pMHC binding induces CD3 dynamics through conformational changes, with the TCRβ FG loop acting as a gatekeeper and the connecting peptide as a hinge.

bioRxiv · Jul 27, 2022 · PreprintMolecular Biology