Mark E. Pepin

This study identifies epigenomic changes in circulating T cells associated with aortic valve stenosis, showing a methylation risk score correlates with hemodynamic severity.

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.

This study shows that somatic HDAC4-902fs mutations cause loss of HDAC4 function via nonsense-mediated mRNA decay, leading to premature ossification and early death in mice.

This study identifies transcriptional regulators and networks mediating islet adaptation during pregnancy through transcriptomic analysis of beta-cells in mice.