ImmunologyImmunityPeer-reviewed
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
Hua Jiang, Sam P. Limsuwannarot, Kayla R. Kulhanek…·Anusha K. Kalbasi
The paper shows that T cells engineered with IL-9R have better tissue infiltration, stemness, and anti-tumor activity compared to those with an orthogonal IL-9 receptor, due to stronger and more specific JAK/STAT signaling.
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