Pieter Derdeyn

Neural circuit basis of adolescent THC-induced potentiation of opioid responses in adult mice

This study investigates how adolescent THC exposure affects adult morphine responses, finding increased reward and altered brain connectivity.

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity

This study identifies molecular and circuit mechanisms in the globus pallidus that regulate cocaine-induced behavioral plasticity, showing that GPePV cell activity predicts and modulates cocaine reward and sensitization.

Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation

This study maps cilia length and orientation across mouse brain regions over 24 hours, revealing region-specific circadian rhythms and non-random orientation patterns.

Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

The paper uses rabies virus tracing to identify drug-induced changes in connectivity to midbrain dopamine cells and links these changes to gene expression patterns.

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement

This study identifies a midbrain dopamine projection to the amygdala that mediates cocaine withdrawal-induced anxiety and reinstatement of drug-seeking behavior.