Kevin Thomas Beier

This study shows that KORs in aPVT neurons mediate morphine withdrawal, anxiety, and fear in both sexes, but only contribute to KOR agonist-induced aversion in males.

This paper introduces a RNA vector that replicates specifically in cancer cells with hyperactive HER2, showing lower toxicity and better efficacy against ovarian cancer in mice, and synergizes with chemotherapy.

This study shows that stress reduces persistent firing in parietal cortex neurons by altering both excitatory and inhibitory synaptic transmission.

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.

This study investigates how adolescent THC exposure affects adult morphine responses, finding increased reward and altered brain connectivity.

This study identifies heightened LC-NE neuron activity and altered connectivity as causes of sleep fragmentation and memory deficits in a 16p11.2 deletion ASD mouse model.

This study identifies molecular and circuit mechanisms in the globus pallidus that regulate cocaine-induced behavioral plasticity, showing that GPePV cell activity predicts and modulates cocaine reward and sensitization.

This study shows acute stress causes sex-dependent changes in vSUB activity, circuitry, and anxiety-like behavior in females but not males.

This study identifies VTAMOR neurons as critical modulators of low sociability during protracted opioid withdrawal and highlights their potential as a therapeutic target.

The paper analyzes inter-cellular communication changes in Alzheimer's Disease using snRNA-seq and CellChat, finding conserved glutamatergic transmission changes in mice and humans.

This study identifies POA glutamatergic neurons as regulators of stress-induced sleep fragmentation through optogenetic manipulation and calcium activity analysis in mice.

This study maps cilia length and orientation across mouse brain regions over 24 hours, revealing region-specific circadian rhythms and non-random orientation patterns.

The paper uses rabies virus tracing to identify drug-induced changes in connectivity to midbrain dopamine cells and links these changes to gene expression patterns.

The paper uses a modified viral-genetic strategy to assess both local and long-range inputs to ventral tegmental area dopamine cells, revealing that nearly half of their inputs are local.

This study identifies a midbrain dopamine projection to the amygdala that mediates cocaine withdrawal-induced anxiety and reinstatement of drug-seeking behavior.

This study investigates how birth timing influences the wiring and physiological response properties of cerebellar granule cells by comparing early- and late-born cells using viral tracing and in vivo imaging.