This paper engineers a sodium/iodide symporter variant that selectively transports oxyanions over iodide, enabling targeted cancer therapy without harming the thyroid.

bioRxiv · Oct 7, 2025 · PreprintBiophysics

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity

Guilian Tian, Katrina Bartas, May Hui, Lingxuan Chen, Jose J Vasquez, Ghalia Azouz, Pieter Derdeyn, Rían W. Manville, Erick L. Ho, Amanda S. Fang, Yuan Li, Isabella Tyler, Vincent Setola, Jason N. Aoto, Geoffrey Winston Abbott, Kevin Thomas Beier

This study identifies molecular and circuit mechanisms in the globus pallidus that regulate cocaine-induced behavioral plasticity, showing that GPePV cell activity predicts and modulates cocaine reward and sensitization.

Neuron · Aug 16, 2024Peer-reviewedNeuroscience

Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations

Elva Martín-Batista, Rían W. Manville, Belinda Rivero-Pérez, David Bartolomé‐Martín, Diego Álvarez de la Rosa, Geoffrey Winston Abbott, Teresa Giráldez

This study shows that SGK1.1 activates the M-current in neurons and can counteract epilepsy-related mutations in Kv7.2 subunits.

Frontiers in Molecular Neuroscience · Nov 26, 2021Peer-reviewedNeuroscience