Gürsel Çalışkan

Autism-like behavior induced by conditional ablation of the Bassoon gene in GABAergic interneurons

This study shows that conditional ablation of the Bassoon gene in GABAergic interneurons leads to autism-like behaviors and synaptic dysfunction in mice.

Modelling Fragile X-Associated Neuropsychiatric Disorders in Young Inducible 90CGG Premutation Mice

This study uses a doxycycline-inducible 90CGG mouse model to show that FXAND features progress from hyperactivity to anxiety to motor dysfunction, with reversible electrophysiological and proteomic changes.

Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

This study shows that increasing NPYergic transmission in the hippocampus of aged male mice rescues deficits in long-term potentiation in the dentate gyrus.

Sex differences in anxiety and threat avoidance in GAD65 knock-out mice

The paper investigates sex differences in anxiety and threat avoidance in GAD65-/- mice, finding sex-specific changes in interneuron populations and neural oscillations in anxiety-related brain regions.

Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

Choosing memory retrieval strategies: a critical role for inhibition in the dentate gyrus

This study shows that the dentate gyrus mediates stress-induced shifts in memory retrieval strategies in mice by regulating excitability through GAD65.

Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization.

The paper shows that NPYergic circuitry in the dorsal dentate gyrus regulates remote fear memory generalization in mice through engram cell activity and neurotransmission recovery.

Antibiotic treatment induces activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus

This study shows that antibiotic treatment in mice reduces synaptic transmission and cholinergic gamma oscillations in the hippocampus, linked to microglia activation and immune changes.

Hippocampal gamma-band oscillopathy in a mouse model of Fragile X Syndrome

This study investigates gamma oscillations in FMR1 KO mice and finds altered power and synchronicity in response to specific agonists, suggesting disrupted signaling pathways in FXS.