Lea C. Steffes

This study shows imatinib lowers right ventricular systolic pressure without affecting vascular remodeling in a mouse model of pulmonary hypertension.

This study develops a mouse model of TBX4-related pulmonary hypertension and shows excessive postnatal smooth muscle differentiation in multiple lung compartments.

The paper presents a single cell multiomic atlas of human lung development, identifying regulatory elements and gene programs, and linking genetic variants to pulmonary function.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.