Mark A. Krasnow

The paper analyzes centromere evolution in lemurs using long-read sequencing, finding rapid sequence turnover and distinct centromeric repeats across species.

The paper identifies Igf2 as an injury-activated mitogen for neuroendocrine stem cells and shows its role in cancer initiation through receptor activation and Rb repression.

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

The paper presents a single cell multiomic atlas of human lung development, identifying regulatory elements and gene programs, and linking genetic variants to pulmonary function.

The paper identifies and characterizes quiescent stem cells in a non-human primate, showing their in vivo self-renewal and similarity to human cells.

The paper identifies a magnesium transporter, SLC41A2, as critical for primate cardiac pacemaker function using a mouse lemur model of arrhythmias.

This study identifies FGF signaling as critical for specifying and maintaining alveolar type 2 (AT2) cells, with implications for lung disease and cancer.

The paper uses single-cell RNA sequencing to identify and characterize neuropeptide and peptide hormone genes in pulmonary neuroendocrine cells from mice and humans, revealing their diverse signaling roles and potential endocrine functions.

This paper uses a mouse lemur transcriptomic atlas to identify new genes, splice junctions, and disease-related features, highlighting their relevance to primate biology and human disease.

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

This study maps MHC class I and II expression across all cell types in mouse lemurs using single-cell RNA sequencing data from the Tabula Microcebus atlas, identifying three expression patterns and their association with cell types.

The paper reports a direct budding mechanism of alveolar development distinct from the classical model of subdivision of large air sacs.

The paper creates an organism-wide hormone signaling atlas in mouse lemurs, identifying hormone-producing and -target cells and revealing species-specific rewiring and conservation compared to humans and mice.

The paper creates a comprehensive cell atlas of mouse lemurs using single-cell RNA sequencing, identifying over 750 cell types and comparing their molecular profiles to humans, mice, and macaques.

The paper presents a transcriptomic atlas of mouse lung interoceptors, identifying 10 molecular subtypes with distinct functional roles in breathing control.

The paper introduces SpliZ, a statistical method to detect cell-type-specific splicing regulation in single-cell RNA-seq data, finding 9.1% of genes show such regulation in human tissues.

The paper creates a comprehensive molecular cell atlas of the human lung using single-cell RNA sequencing, identifying 58 cell populations including 14 new types and revealing evolutionary changes in lung cell types.

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.