Author

Rafael P. Vázquez‐Manrique

Centre for Biomedical Network Research on Rare DiseasesORCID 0000-0002-1594-0033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

María Dolores SequedoiD· 2 shared Agustín LahoziD· 1 shared Alessandro LiquoriiD· 1 shared Ana Pilar Gómez-EscribanoiD· 1 shared Ángel Cedazo-Mı́ngueziD· 1 shared Antonio Miranda‐VizueteiD· 1 shared Antonio Rosal‐VelaiD· 1 shared Beatriz Sáenz‐NarcisoiD· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

María Dolores SequedoORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintDec 8, 2021

Opposing steroid signals modulate protein homeostasis through deep changes in fat metabolism in Caenorhabditis elegans

Ana Pilar Gómez-Escribano, Carlos Mora‐Martínez, Marta Roca…·Rafael P. Vázquez‐Manrique

The paper shows that UNC-1 in C. elegans neurons modulates protein homeostasis by altering fat metabolism through neurohormonal signaling involving NHR-1 and DAF-12.

2 citations

C. elegansstatistical model

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Molecular BiologybioRxivPreprintOct 25, 2021

Alternative strategy to induce CRISPR-mediated genetic changes in hematopoietic cells

E González-Romero, Antonio Rosal‐Vela, Alessandro Liquori…·Rafael P. Vázquez‐Manrique

The paper presents a CRISPR-mediated method for inducing genetic changes in hematopoietic cells using PCR-generated constructs, showing comparable efficiency to ribonucleoprotein strategies without off-target effects.

DOI 10.1101/2021.10.25.465699

humanCRISPR screen

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GeneticsCell Death and DifferentiationPeer-reviewedFeb 15, 2019

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

David Guerrero‐Gómez, José Antonio Mora-Lorca, Beatriz Sáenz‐Narciso…·Antonio Miranda‐Vizuete

This study shows that loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation in C. elegans and other organisms.

41 citations

C. elegansyeast

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