José Antonio Mora-Lorca

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

This study shows that loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation in C. elegans and other organisms.