Author

Mia Shin

Scripps Research InstituteORCID 0000-0002-1607-5301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

Gabriel C. LanderiD· 3 shared R. Luke WisemaniD· 3 shared Cristina PuchadesiD· 2 shared A. Wali KarzaiiD· 1 shared Albert S. SongiD· 1 shared Ananya AsmitaiD· 1 shared Anthony J. RampelloiD· 1 shared Christopher J. GiulianoiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Gabriel C. LanderORCID

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3 papers

Recent·Most cited

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander

This study determines the cryo-EM structures of human LONP1 to elucidate the molecular mechanism of its proteolytic activation and regulation.

Nature Communications · May 28, 2021Peer-reviewedMolecular Biology

Distinct Structural Features of the Lon Protease Drive Conserved Hand-over-Hand Substrate Translocation

Mia Shin, Ananya Asmita, Cristina Puchades, Eric Adjei, R. Luke Wiseman, A. Wali Karzai, Gabriel C. Lander

The paper determines the cryo-EM structure of Y. pestis Lon protease during substrate processing, revealing a distinct hand-over-hand translocation mechanism unique to the HCLR clade.

bioRxiv · Apr 24, 2019 · PreprintMolecular Biology

Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing

Cristina Puchades, Anthony J. Rampello, Mia Shin, Christopher J. Giuliano, R. Luke Wiseman, Steven E. Glynn, Gabriel C. Lander

The paper presents the first atomic structure of the mitochondrial inner membrane AAA+ protease YME1, revealing its mechanism of substrate processing and translocation.

Science · Nov 2, 2017Peer-reviewedMolecular Biology