Devika Soundara Manickam

The paper shows that mitochondrial and bioenergetic processes are enriched in large EVs but depleted in small EVs using proteomics and gene-set enrichment analysis.

This study compares extracellular vesicles from bioreactor and batch cultures of brain endothelial cells, finding similar functional properties and protein content, with bioreactor cultures producing higher yields.

This study shows that purinergic receptor activation can correct endothelial dysfunction linked to autism in a mouse model by restoring bioenergetic function and cerebrovascular reactivity.

The paper compares sequential centrifugation and density gradient centrifugation for isolating mitochondria-containing large extracellular vesicles.

This study shows that mitochondria-containing large extracellular vesicles (lEVs) improve mitochondrial function in heat-stressed neurons and deliver mitochondria to motor neurons in vivo.

This study shows that ionic liquid-coated lipid nanoparticles can hitchhike on red blood cells, improving brain uptake and circulation time compared to uncoated nanoparticles.

This study compares the therapeutic efficacy of mitochondria-containing extracellular vesicles from mouse and human brain endothelial cells in a mouse stroke model, finding that mouse-derived vesicles are more effective.