Zuohui Zhang

Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice

This study shows that deficiency of MANF worsens acute pancreatitis in mice, with sex-specific effects on inflammation and oxidative stress.

Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

This study shows alcohol disrupts neural differentiation by inducing ER stress and PERK pathway activation in both in vitro and in vivo models of prenatal alcohol exposure.

Age-Related Alterations in the Expression of Mesencephalic Astrocyte-derived Neurotrophic Factor in the Brain and Their Impact on Neurobehavioral Functions

This study shows that MANF levels decline with age in mice and that MANF deficiency affects neurobehavioral functions differently in males and females.

Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice

This study investigates how alcohol affects the gut microbiome in adolescent and adult MMTV-Wnt1 mice and their wild-type counterparts, showing reduced microbiome richness and altered composition.

Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice

This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.