Brígida R. Pinho

This paper develops a motor endurance assay for zebrafish larvae to study neurological diseases, finding reduced endurance in TDP43-overexpressing larvae and MPP+-treated larvae.

This study shows that inhibiting the mitochondrial pyruvate carrier modulates the integrated stress response differently in wild-type and mutant huntingtin-expressing cells.

This study uses zebrafish to model Wolcott-Rallison syndrome by inhibiting PERK with GSK2606414, revealing developmental defects consistent with the syndrome.

This study shows that the E134K mutation in SMN disrupts its interaction with GAR1, impairing phase separation and contributing to spinal muscular atrophy.