Author

Philip O’Toole

Unidade em Ciências Biomoleculares AplicadasORCID 0000-0002-4995-7255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Eurico J. CabritaiD· 2 shared Sara S. FélixiD· 2 shared Aldino ViegasiD· 1 shared Angelo Miguel FigueiredoiD· 1 shared Brígida R. PinhoiD· 1 shared Douglas V. LaurentsiD· 1 shared Fábio FernandesiD· 1 shared Javier OroziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

Eurico J. CabritaORCID

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2 papers

Recent·Most cited

NMR reveals specific remodelling of protein folding landscapes in ionic liquids

Micael S. Silva, Aldino Viegas, Philip O’Toole, Sara S. Félix, Angelo Miguel Figueiredo, Eurico J. Cabrita

This paper shows ionic liquids modulate protein folding by stabilizing or destabilizing folded/unfolded states through distinct mechanisms, challenging the conventional view of protein stabilization.

International Journal of Biological Macromolecules · Feb 28, 2026Peer-reviewedBiophysics

Pathological mutation in SMN impairs modulation of GAR1 phase separation linking condensate dysfunction to Spinal Muscular Atrophy

Sara S. Félix, Philip O’Toole, Nuno A. S. Oliveira, Brígida R. Pinho, Thomas S. Blacker, Fábio Fernandes, Jorge M. A. Oliveira, Javier Oroz, Douglas V. Laurents, Eurico J. Cabrita

This study shows that the E134K mutation in SMN disrupts its interaction with GAR1, impairing phase separation and contributing to spinal muscular atrophy.

bioRxiv · Jan 30, 2025 · PreprintBiochemistry