Jorge M. A. Oliveira

A motor endurance assay for zebrafish larvae: proof of principle in chemical and genetic models of neurological disease

This paper develops a motor endurance assay for zebrafish larvae to study neurological diseases, finding reduced endurance in TDP43-overexpressing larvae and MPP+-treated larvae.

Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease

This study shows that inhibiting the mitochondrial pyruvate carrier modulates the integrated stress response differently in wild-type and mutant huntingtin-expressing cells.

PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes

This study uses zebrafish to model Wolcott-Rallison syndrome by inhibiting PERK with GSK2606414, revealing developmental defects consistent with the syndrome.

Pathological mutation in SMN impairs modulation of GAR1 phase separation linking condensate dysfunction to Spinal Muscular Atrophy

This study shows that the E134K mutation in SMN disrupts its interaction with GAR1, impairing phase separation and contributing to spinal muscular atrophy.