Sarah E. Allen

The paper shows that di-valent siRNA reduces wild-type Htt mRNA but not mutant HTT mRNA in HD mouse models, with mutant transcripts remaining clustered in the nucleus.

This paper introduces a dual-targeting di-valent siRNA scaffold that can silence two genes simultaneously in the CNS of mice, demonstrating potent and programmable multi-gene modulation.

The paper improves CRISPR/Cas9 tools for tissue-specific mutagenesis in Drosophila by enhancing gRNA efficiency, enabling cell labeling, and providing genetic reagents for flexible Cas9 deployment.

The paper introduces MAGIC, a CRISPR/Cas9-based method to generate mosaic animals in Drosophila by inducing DNA double-strand breaks, enabling efficient gene function studies and fluorescent clone generation.

This paper reports the genome and transcriptome of the subterrestrial nematode Halicephalobus mephisto, identifying adaptations to heat stress including expanded Hsp70 genes and horizontally transferred AIG1 genes.