Heidi May McBride

STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

The paper shows STING dampens the unfolded protein response to allow self-antigen presentation on MHC-I during inflammation, linking it to immune regulation in Parkinson's disease.

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

The paper shows LRRK2 mutations impair NCOA4 trafficking during iron overload, causing ferroptotic cell death in macrophages.

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models

This study shows that PINK1 in myeloid cells represses mtDNA release and immune signaling, which contributes to neuronal pathology in Parkinson's disease models.

A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1 knock out mouse model of Parkinsons disease

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

This study shows that a single Citrobacter rodentium infection increases blood-brain barrier permeability and triggers neuroinflammation in Pink1 knockout mice without dopamine neuron loss.

TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

The paper identifies TRAF6 as an interactor of misfolded SOD1 in ALS, showing it promotes aggregation through ubiquitination.

Implementation of an antibody validation procedure: Application to the major ALS/FTD disease gene C9ORF72

The paper validates antibodies against the C9ORF72 protein, finding one specific monoclonal antibody and highlighting issues with others used in published studies.