Daniel Beaudet

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

The paper identifies axonal cytoskeletal responses to mechanical forces and shows that mechanotransduction signaling is critical for axonal integrity.

This study shows that tau hyperphosphorylation disrupts cooperative microtubule binding and impairs lysosome trafficking in neurons, contributing to neurodegeneration.