Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation
Carla Lucia Esposito, Ida Autiero, Annamaria Sandomenico, Haiqing Li, Mahmoud Adel Bassal, Maria Luigia Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr M. Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, , Annalisa Di Ruscio
This paper develops an RNA-based aptamer, aptaDiR, that neutralizes DNMT1 function to block DNA methylation and impair cancer cell viability.
Nature Communications · Jan 6, 2023Peer-reviewedMolecular Biology