Author

Lucrezia Rinaldi

Beth Israel Deaconess Medical CenterORCID 0000-0002-3054-8072Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander K. Ebralidze· 3 shared Annalisa Di RuscioiD· 3 shared Giulia GaggiiD· 3 shared Mahmoud Adel BassaliD· 3 shared Marta BorchielliniiD· 3 shared Simone UmmarinoiD· 3 shared Barbara GhinassiiD· 2 shared Susumu S. KobayashiiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersMolecular Biology

Alexander K. Ebralidze

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 29, 2025

Small activating RNA AW1-51 (CEBPA-51) elicits targeted DNA demethylation to promote gene activation

Giulia Gaggi, Juan Rodrigo Patiño-Mercau, Marta Borchiellini…·Annalisa Di Ruscio

This study identifies the mechanism by which AW1-51, a small activating RNA, promotes DNA demethylation and reactivation of the CEBPA gene in cancer.

3 citations

humanDNA methylation

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedJan 6, 2023

Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation

Carla Lucia Esposito, Ida Autiero, Annamaria Sandomenico…·Annalisa Di Ruscio

This paper develops an RNA-based aptamer, aptaDiR, that neutralizes DNMT1 function to block DNA methylation and impair cancer cell viability.

29 citations

DNA methylationexperimental assay

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Molecular BiologyCellsPeer-reviewedNov 2, 2021

NAD modulates DNA methylation and cell differentiation

Simone Ummarino, Clinton Hausman, Giulia Gaggi…·Annalisa Di Ruscio

This study shows that NAD affects DNA methylation and cell differentiation by promoting ADP-ribosylation of DNMT1, leading to CEBPA activation and myeloid differentiation.

28 citations

humanDNA methylation

𝕏 PostBluesky