Author

Marta Borchiellini

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”ORCID 0000-0002-8395-0540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander K. Ebralidze· 3 shared Annalisa Di RuscioiD· 3 shared Giulia GaggiiD· 3 shared Lucrezia RinaldiiD· 3 shared Mahmoud Adel BassaliD· 3 shared Simone UmmarinoiD· 3 shared Barbara GhinassiiD· 2 shared Susumu S. KobayashiiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersMolecular Biology

Alexander K. Ebralidze

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3 papers

Recent·Most cited

Small activating RNA AW1-51 (CEBPA-51) elicits targeted DNA demethylation to promote gene activation

Giulia Gaggi, Juan Rodrigo Patiño-Mercau, Marta Borchiellini, Mailin Li, Lucrezia Rinaldi, Giorgia Maroni, Davide D’Onghia, Susumu S. Kobayashi, Mahmoud Adel Bassal, Nagy Adley Habib, Pedro P. Medina, Angela Di Baldassarre, Barbara Ghinassi, Alexander K. Ebralidze, Simone Ummarino, , Annalisa Di Ruscio

This study identifies the mechanism by which AW1-51, a small activating RNA, promotes DNA demethylation and reactivation of the CEBPA gene in cancer.

bioRxiv · Sep 29, 2025 · PreprintMolecular Biology

Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation

Carla Lucia Esposito, Ida Autiero, Annamaria Sandomenico, Haiqing Li, Mahmoud Adel Bassal, Maria Luigia Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr M. Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, , Annalisa Di Ruscio

This paper develops an RNA-based aptamer, aptaDiR, that neutralizes DNMT1 function to block DNA methylation and impair cancer cell viability.

Nature Communications · Jan 6, 2023Peer-reviewedMolecular Biology

NAD modulates DNA methylation and cell differentiation

Simone Ummarino, Clinton Hausman, Giulia Gaggi, Lucrezia Rinaldi, Mahmoud Adel Bassal, Yanzhou Zhang, Andy Joe Seelam, Ikei S. Kobayashi, Marta Borchiellini, Alexander K. Ebralidze, Barbara Ghinassi, Bon Q. Trinh, Susumu S. Kobayashi, Annalisa Di Ruscio

This study shows that NAD affects DNA methylation and cell differentiation by promoting ADP-ribosylation of DNMT1, leading to CEBPA activation and myeloid differentiation.

Cells · Nov 2, 2021Peer-reviewedMolecular Biology