Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids.
Erik Vrij, Yvonne Scholte op Reimer, Javier Frias-Aldeguer, Isabel Misteli Guerreiro, Jop Kind, Bon‐Kyoung Koo, Clemens van Blitterswijk, Nicolas C. Rivron
The paper shows that chemically-defined conditions and signaling molecules can generate primitive endoderm-like cells and support post-implantation-like epiblast development in vitro.
bioRxiv · Apr 12, 2019 · PreprintDevelopmental Biology