Javier Frias-Aldeguer

This paper shows HBx promotes hepatocyte survival and reduces differentiation in human liver organoids, potentially contributing to liver cancer.

The paper shows that embryonic signals convert trophoblast stem cells into polar-like cells that pattern the blastocyst axis in vitro.

This paper introduces scPECLR, a probabilistic algorithm that reconstructs cellular lineage trees at single-cell division resolution using 5-hydroxymethylcytosine sequencing in mouse embryos.

The paper maps gene expression changes during meiotic prophase-I in mice spermatogenesis, identifying key transitions and gene regulation patterns.

The paper shows that chemically-defined conditions and signaling molecules can generate primitive endoderm-like cells and support post-implantation-like epiblast development in vitro.