Bon‐Kyoung Koo

This paper develops a label-free 3D holotomography method to track lipid droplet dynamics in hepatic organoids under different fatty-acid treatments, revealing distinct accumulation strategies.

This study shows that Stmn1-lineage cells contribute to acinar regeneration but not to neoplasia when KrasG12D is expressed.

This study identifies WNK kinases as regulators of RNF43, showing they control RNF43 membrane levels and WNT signaling, with implications for cancer therapy.

This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.

The paper introduces Red2Flpe-SCON, a multicolor system for generating mosaic conditional knockout mice, and uses it to show Sox2 is not essential for stem cell maintenance but for proliferation and differentiation.

This study shows that NOTCH3 signaling regulates human trophoblast stem cell expansion and differentiation, with implications for placental development and pregnancy disorders.

This study introduces low-coherence holotomography for long-term live imaging of unlabeled mouse small intestinal organoids, capturing high-resolution morphological details and differentiating viable from non-viable organoids.

This paper introduces SCON, a short conditional intron for conditional knockout via one-step zygote injection, showing its function across vertebrate species.

This study shows that low Sox2 expression in naive pluripotent stem cells enhances their developmental plasticity without impairing neuroectoderm differentiation.

The paper investigates the mutational impact of ionizing radiation on normal cells and confirms these signatures in IR-induced cancers.

The paper shows that chemically-defined conditions and signaling molecules can generate primitive endoderm-like cells and support post-implantation-like epiblast development in vitro.