Lukas K. Tamm

This study investigates how Munc18 interacts with Syntaxin and SNAP25 in model membranes, showing lipid-dependent effects on SNARE complex assembly and exocytosis.

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

This paper designs stable transmembrane beta-barrel nanopores with tailored sizes and shapes using de novo protein design, achieving conductances ranging from 110 pS to 430 pS.

This study successfully designs transmembrane beta-barrels from first principles, revealing structural constraints and enabling custom pore design for biotechnology applications.

The paper shows that conserved arginine residues in synaptotagmin 1's C2B domain regulate fusion pore expansion by interacting with membranes during neurotransmitter release.