Volker Kiessling

Munc18 binds to and organizes membrane-bound acceptor Q-SNARE complexes in a fashion that depends on the membrane's lipid composition

This study investigates how Munc18 interacts with Syntaxin and SNAP25 in model membranes, showing lipid-dependent effects on SNARE complex assembly and exocytosis.

DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

Conserved Arginine Residues in Synaptotagmin 1 Regulate Fusion Pore Expansion Through Membrane Contact

The paper shows that conserved arginine residues in synaptotagmin 1's C2B domain regulate fusion pore expansion by interacting with membranes during neurotransmitter release.