Binyong Liang

The paper identifies a non-lytic bactericidal mechanism in P. aeruginosa by targeting multiple transporters and transcription, leading to respiratory suppression and bacterial death.

This paper designs stable transmembrane beta-barrel nanopores with tailored sizes and shapes using de novo protein design, achieving conductances ranging from 110 pS to 430 pS.

This study successfully designs transmembrane beta-barrels from first principles, revealing structural constraints and enabling custom pore design for biotechnology applications.

The paper shows that conserved arginine residues in synaptotagmin 1's C2B domain regulate fusion pore expansion by interacting with membranes during neurotransmitter release.