Ivan Sadowski

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T-cells

The paper shows that CBP/p300 inhibitors reverse HIV-1 latency in T-cells by altering acetylation at the HIV-1 LTR, and that this effect is distinct from HDACi mechanisms.

Upstream Stimulatory Factors regulate HIV-1 latency and are required for robust T cell activation

The paper investigates the role of USF1 and USF2 in HIV-1 latency and T cell activation, finding that USF2 is critical for HIV-1 expression and combined function with USF1 is necessary for full T cell activation.

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation

This study shows TRIM24, recruited by TFII-I to the HIV-1 LTR, facilitates transcriptional elongation by enabling P-TEFb recruitment, essential for HIV-1 reactivation.

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

This study shows that inhibiting TRIM24's bromodomain with IACS-9571 reactivates latent HIV-1 without broadly activating T cells.

Cdk8 directly regulates glycolysis via phosphorylation of Gcr2

This study identifies Gcr2 as a Cdk8 substrate, showing its phosphorylation is critical for activating glycolysis genes.

TOR signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae

The paper identifies TOR signaling's role in modulating Cdk8-dependent GAL gene expression in yeast by showing its interaction with PP2A/Cdc55.