Author

Mariel O. Brok

Princess Máxima CenterORCID 0000-0001-6018-900XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Frank C. P. HolstegeiD· 3 shared Patrick KemmereniD· 3 shared Wim J. de JongeiD· 3 shared Philip LijnzaadiD· 2 shared Annelisa M. CorneliD· 1 shared Baojie ZhangiD· 1 shared Bart VandekerckhoveiD· 1 shared Charlotte op ’t HoogiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Frank C. P. HolstegeORCID

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4 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedOct 31, 2026

Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors.

Juliane L. Buhl, Jannet Koelewijn, Charlotte op ’t Hoog…·Claudia Y. Janda

1 citation

humanproteomics

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Molecular BiologybioRxivPreprintMar 12, 2021

Cdk8 directly regulates glycolysis via phosphorylation of Gcr2

Maria J. Aristizabal, Eoghan O’Duibhir, Wim J. de Jonge…·Ivan Sadowski

This study identifies Gcr2 as a Cdk8 substrate, showing its phosphorylation is critical for activating glycolysis genes.

1 citation

statistical model

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Molecular BiologyMolecular Systems BiologyPeer-reviewedOct 1, 2020

Genome-wide off-rates reveal how DNA binding dynamics shape transcription factor function

Wim J. de Jonge, Mariel O. Brok, Philip Lijnzaad…·Frank C. P. Holstege

The paper measures genome-wide off-rates of the yeast transcription factor Abf1 and shows how these dynamics relate to functional outcomes like transcriptional dependency and RNA polymerase II roadblocking.

18 citations

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Molecular BiologySTAR ProtocolsPeer-reviewedJun 1, 2020

An extensively optimized chromatin immunoprecipitation protocol for quantitatively comparable and robust results

Wim J. de Jonge, Mariel O. Brok, Patrick Kemmeren, Frank C. P. Holstege

The paper optimizes a ChIP protocol to improve quantitative comparability and reproducibility across samples.

32 citations

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