Magellan Tchouakui

Multi-site phenotypic characterisation of Kisumu colonies for comparison of insecticide susceptibility between testing centres

This study compares insecticide susceptibility of Kisumu mosquito colonies across 16 facilities, finding significant variability in susceptibility to different insecticides.

Genome-wide association studies unveil major genetic loci driving insecticide resistance in Anopheles funestus in four eco-geographical settings across Cameroon

A single mutation G454A in P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b drive pyrethroid resistance in Anopheles funestus

This study identifies two mutations in CYP6P4a and CYP6P4b genes driving pyrethroid resistance in Anopheles funestus and develops DNA-based assays to detect these mutations in West Africa.

A single E205D allele of a key P450 CYP6P3 is driving metabolic pyrethroid resistance in the major African malaria vector Anopheles gambiae

This study identifies the E205D mutation in CYP6P3 as a driver of pyrethroid resistance in Anopheles gambiae, showing its association with resistance and its interaction with kdr mutations.

Xeno-monitoring of molecular drivers of artemisinin and partner drug resistance in P. falciparum populations in malaria vectors across Cameroon

The paper analyzes genetic resistance markers in Plasmodium falciparum from malaria vectors in Cameroon to assess artemisinin and partner drug resistance.

Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus

This study investigates how metabolic resistance genes affect blood feeding in Anopheles funestus, finding that CYP6P9a resistance increases blood feeding success and meal size.