Author

Jaroslav Žák

Scripps Research InstituteORCID 0000-0002-8135-856XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:deep learning· 1 Assay:imaging· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Adam Ramadan· 1 shared Andrew LuiiD· 1 shared Andrew ZissermaniD· 1 shared Anghesom GhebremedhiniD· 1 shared Birkley S. LimiD· 1 shared Carlos ArtetaiD· 1 shared Chao WangiD· 1 shared Daniel J. Montiel GarciaiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperCancer Biology

Adam Ramadan

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Author profile →

4 papers

Recent·Most cited

An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

Jaroslav Žák, Hui Chen, Erpei Wang, Patrick Ozark, Giuliana P. Mognol, MATTHEW Dae-Young PARK, Nadine Fournier, Priyanka Chaudary, Jingjing Hu, Ryan M. Shepard, Anghesom Ghebremedhin, Marc A. Paradise, Jason Rivera, William J Harris, Zihan Xu, , Judith A. Varner

This study identifies an IL-34-IGF-1 axis between macrophages and KRAS-mutant lung tumor cells that promotes tumor progression and poor survival.

bioRxiv · Jul 15, 2026 · PreprintCancer Biology

Catalyzing computational biology research at an academic institute through an interest network

Jaroslav Žák, Ian A. Newman, Daniel J. Montiel Garcia, Daniele Parisi, Janet Joy, Steven Robert Head, Jean-Christophe Ducom, Padmaja Natarajan, Haissi Cui, Sabah Ul-Hasan

The paper describes how a volunteer-led affinity group enhances computational biology skills and networking among researchers at an academic institute.

PLoS Computational Biology · Sep 10, 2025Peer-reviewedBioinformatics

Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9

Chao Wang, Yingqin Hou, Jaroslav Žák, Qinheng Zheng, Kelli A. McCord, Mengyao Wu, Ding Zhang, Shereen Chung, Yujie Shi, Jinfeng Ye, Yunlong Zhao, Stephanie Hajjar, Ian A. Wilson, James C. Paulson, John Ross Teijaro, , Peng Wu

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.

bioRxiv · Oct 11, 2024 · PreprintImmunology

HTX: a tool for the exploration and visualization of high-throughput image assays

Carlos Arteta, Victor Lempitsky, Jaroslav Žák, Andrew Lui, J. Alison Noble, Andrew Zisserman

HTX is an interactive tool for exploring and visualizing high-throughput image assays, using novel algorithms to learn image descriptors and quantify visual similarities between samples.

Science Advances · Apr 6, 2018Peer-reviewedBioinformatics