Author

Yingqin Hou

Scripps Research InstituteORCID 0000-0002-0330-040XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

Jinfeng YeiD· 2 shared Peng WuiD· 2 shared Shereen Chung· 2 shared Wenjian WangiD· 2 shared Yujie ShiiD· 2 shared Alexander G. GabiboviD· 1 shared Alexey V. StepanoviD· 1 shared Chao WangiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Jinfeng YeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells

Yingqin Hou, Jinfeng Ye, Ke Qin, Leigh-Ann Cui, Shereen Chung, Digantkumar Gopaldas Chapla, Wenjian Wang, Yujie Shi, Mingkuan Chen, Kelley W. Moremen, Robert Sackstein, Peng Wu

This study shows that exofucosylation of T cells enhances their homing and therapeutic efficacy in treating solid tumors and metastases.

bioRxiv · Jan 12, 2025 · PreprintCancer Biology

Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9

Chao Wang, Yingqin Hou, Jaroslav Žák, Qinheng Zheng, Kelli A. McCord, Mengyao Wu, Ding Zhang, Shereen Chung, Yujie Shi, Jinfeng Ye, Yunlong Zhao, Stephanie Hajjar, Ian A. Wilson, James C. Paulson, John Ross Teijaro, , Peng Wu

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.

bioRxiv · Oct 11, 2024 · PreprintImmunology

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova, Wenjian Wang, Yingqin Hou, Dmitry Pershin, Maria Fadeeva, Ekaterina A. Malakhova, Elena A. Kulakovskaya, LYU Cuicui, Zhao Mingfeng, Hongkai Zhang, Jia Xie, Ding Zhang, Ilgar Z. Mamedov, , Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

Molecular Therapy Oncology · Jun 27, 2024Peer-reviewedMolecular Biology