Leighton J. Core

The paper identifies novel enhancer elements that regulate MyoD expression during skeletal muscle development and show they are part of a cis-regulatory network.

The paper identifies centromeric transposable elements and epigenetic features in the eastern hoolock gibbon that contribute to karyotypic variation and chromosomal instability.

The paper presents the first de novo repeat discovery and annotation of a complete human reference genome, identifying novel satellite arrays and characterizing new classes of complex repeats.

This study shows that antisense oligonucleotides targeting UBE3A-ATS restore UBE3A expression by removing transcriptional interference in Angelman syndrome neurons.

The paper identifies multiple regulatory mechanisms that control transcription reactivation during the mitosis-G1 transition using PRO-seq.

This study shows that H3K27 acetylation retention during mitosis accelerates transcriptional and topological resetting of stem cell genes in mouse pluripotent stem cells upon G1 entry.

A precision run-on sequencing (PRO-seq) variant with one streptavidin bead binding and on-bead enzymatic steps yields adapter-ligated cDNA in about 10 h and libraries from 0.05–0.25 × 10^6 cells.

The paper improves the auxin-inducible degron system to enable rapid, specific protein depletion while preserving native protein levels and patterns.

This study identifies a bipartite boundary element that restricts UBE3A antisense transcript expression to neurons, essential for UBE3A imprinting in Angelman syndrome.

This study introduces ChRO-seq to map nascent transcription in glioblastoma and identifies enhancers and transcription factors driving GBM subtypes and clinical outcomes.