Mariam Okhovat

Early-Life Wildfire Smoke Exposure Is Associated with Long-Term Systemic Immune Remodeling and Epigenetic Reprogramming

This study shows that early-life wildfire smoke exposure in rhesus macaques leads to long-term immune and epigenetic changes, including altered cytokine responses and accelerated epigenetic aging.

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model

This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.

Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon

The paper identifies centromeric transposable elements and epigenetic features in the eastern hoolock gibbon that contribute to karyotypic variation and chromosomal instability.

Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in mice

This study shows that deleting a conserved TAD boundary near Dmrtb1 and Lrp8 in mice impairs spermatogenesis but not fertility.

De novo assembly and annotation of the singing mouse genome

The paper assembles and annotates the genome of the singing mouse, using single nuclei sequencing to identify cell types in a brain region involved in song coordination.

The genomic false shuffle: epigenetic maintenance of topological domains in the rearranged gibbon genome

This study examines how chromosomal rearrangements in the gibbon genome affect TAD boundaries and epigenetic features, finding overlap between rearrangement breakpoints and TAD boundaries.