Author

Jared R Coombs

The University of QueenslandORCID 0000-0002-1703-1247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Emmanuelle Frampton· 1 shared Jakub BeganiD· 1 shared Jing Rong Chia· 1 shared Joanna CrawfordiD· 1 shared Kate SchroderiD· 1 shared Kirsten Myra KenneyiD· 1 shared Malvina PizzutoiD· 1 shared Masahiro YamamotoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Emmanuelle Frampton

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1 paper

Recent·Most cited

ImmunologyThe EMBO JournalPeer-reviewedJul 16, 2025

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

Malvina Pizzuto, Mercedes M. Monteleone, Sabrina Sofia Burgener…·Kate Schroder

This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.

18 citationstop 3%

experimental assayhost-pathogen & immune response

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