Sabrina Sofia Burgener

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity

This study shows that myeloid HDAC7 promotes liver inflammation and glucose dysregulation in obesity, using mouse models and human data.

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.