Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo
Malvina Pizzuto, Mercedes M. Monteleone, Sabrina Sofia Burgener, Jakub Began, Melan Kurera, Jing Rong Chia, Emmanuelle Frampton, Joanna Crawford, Monalisa Oliveira, Kirsten Myra Kenney, Jared R Coombs, Masahiro Yamamoto, Si Ming Man, Petr Brož, Pablo Pelegrı́n, Kate Schroder
This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.
The EMBO Journal · Jul 16, 2025Peer-reviewedImmunology