ImmunologyThe EMBO JournalPeer-reviewed
Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo
Malvina Pizzuto, Mercedes M. Monteleone, Sabrina Sofia Burgener…·Kate Schroder
This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.
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