In vivo high-content screening in zebrafish for developmental nephrotoxicity of approved drugs
Jens Hendrik Westhoff, Peter J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Thomas M. Bruckner, Ledean Cooper, Burkhard Tönshoff, Georg Friedrich Hoffmann, Jochen Gehrig
The paper screens approved drugs for developmental nephrotoxicity in zebrafish embryos using high-content imaging and analysis tools, identifying 10% of tested drugs as potentially nephrotoxic.
Frontiers in Cell and Developmental Biology · Jul 10, 2020Peer-reviewedDevelopmental Biology