Author

Ledean Cooper

University of Birmingham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:imaging· 2 Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ferenc MülleriD· 2 shared Lucy WheatleyiD· 2 shared Yavor HadzhieviD· 2 shared Agnieszka GambusiD· 1 shared Aleksandra JasiulewicziD· 1 shared Andrew David BeggsiD· 1 shared Attila Gabor SIKiD· 1 shared Burkhard TönshoffiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

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10 top collaborators · 28 mutual co-author links

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2 shared papersDevelopmental Biology

Ferenc MüllerORCID

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3 papers

Recent·Most cited

The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation

Yavor Hadzhiev, Lucy Wheatley, Ledean Cooper, Federico Ansaloni, Celina Whalley, Zhonghao Chen, Sara Finaurini, Stefano Gustincich, Remo Sanges, Shawn Michael Burgess, Andrew David Beggs, Ferenc Müller

The paper identifies a high-density miR-430 promoter cluster that forms a transcription body, enabling early gene activation during the minor wave of zygotic genome activation in zebrafish.

Developmental Cell · Jan 1, 2023Peer-reviewedDevelopmental Biology

In vivo high-content screening in zebrafish for developmental nephrotoxicity of approved drugs

Jens Hendrik Westhoff, Peter J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Thomas M. Bruckner, Ledean Cooper, Burkhard Tönshoff, Georg Friedrich Hoffmann, Jochen Gehrig

The paper screens approved drugs for developmental nephrotoxicity in zebrafish embryos using high-content imaging and analysis tools, identifying 10% of tested drugs as potentially nephrotoxic.

Frontiers in Cell and Developmental Biology · Jul 10, 2020Peer-reviewedDevelopmental Biology

A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activation

Yavor Hadzhiev, Haseeb Khalid Qureshi, Lucy Wheatley, Ledean Cooper, Aleksandra Jasiulewicz, Huy V. Nguyen, Joseph W. Wragg, Divyasree Poovathumkadavil, Sascha Conic, Sarah Bajan, Attila Gabor SIK, György Hutvágner, Làszlò Tora, Agnieszka Gambus, John Fossey, Ferenc Müller

The paper identifies a nuclear transcription compartment that enables early gene expression before genome activation in metazoan embryos.

Nature Communications · Feb 11, 2019Peer-reviewedDevelopmental Biology